lncrna|lncrna in cancer : Tagatay Initial studies into lncRNA conservation noted that as a class, they were enriched for conserved sequence elements, depleted in substitution and insertion/deletion rates and depleted in . See more Anonytun Claro 2024: Las mejores configuraciones Mundiales. por Anonytun APK. Conectar anonytun Claro 2024: Aquí vas a tener todos los trucos de los mejores métodos para tener conexión al internet 3g y 4g lte sin saldo, para ello solo debes seguir las instrucciones. Las configuraciones funcionan en todas . Ver mais
0 · lncrna是什么
1 · lncrnas function
2 · lncrna target prediction
3 · lncrna in cancer
4 · lncrna identification
5 · lncrna gene regulation
6 · lncrna database
7 · lncrna company
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lncrna*******Long non-coding RNAs (long ncRNAs, lncRNA) are a type of RNA, generally defined as transcripts more than 200 nucleotides that are not translated into protein. This arbitrary limit distinguishes long ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), . See moreLong non-coding transcripts are found in many species. Large-scale complementary DNA (cDNA) sequencing projects such as FANTOM reveal the complexity of these transcripts in . See more
In 2005 the landscape of the mammalian genome was described as numerous 'foci' of transcription that are separated by long stretches of intergenic space. While some long ncRNAs are . See morelncrnaThere has been considerable debate about whether lncRNAs have been misannotated and do in fact encode proteins. . See more
Initial studies into lncRNA conservation noted that as a class, they were enriched for conserved sequence elements, depleted in substitution and insertion/deletion rates and depleted in . See more
Despite claims that the majority of long noncoding RNAs in mammals are likely to be functional, it seems likely that most of them are . See more
The discovery that long ncRNAs function in various aspects of cell biology has led to research on their role in disease. Tens of thousands of lncRNAs are potentially associated with diseases based on the multi-omics evidence. A handful of studies have implicated . See more• List of long non-coding RNA databases• NONCODE• Pinc• Sphinx (gene) See more Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase .
Depending on their localization and their specific interactions with DNA, RNA and proteins, lncRNAs can modulate chromatin function, regulate the assembly . Long non-coding RNAs (lncRNAs) are defined as RNAs that have a transcript length exceeding 200 nucleotides and will not be translated into proteins 1. A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as . Long noncoding RNAs (lncRNAs) represent the largest group of non-coding RNAs produced from the genome. LncRNAs are defined as transcripts >200 nucleotides .
In this article, Liu et al. summarize the biological features, biogenesis, and functions of lncRNAs and focus on their mechanisms in gastric cancer (GC) progression .lncrna in cancer In this review, we summarize current knowledge of lncRNA subcellular localization, factors controlling their localization, emerging themes, including the role of .Although modern cells have changed significantly in 4 billion years, RNA has maintained its central role in cell biology. Since the discovery of DNA at the end of the nineteenth .Here, we summarize classification methods of lncRNAs according to their four major features, namely, genomic location and context, effect exerted on DNA sequences, . lncRNA在转录后水平反式调控基因表达 与癌症相关的lncRNA 最后，文章详述了lncRNA在多种病理条件下，包括在神经分化、神经系统疾病、造血、免疫反应、癌症等相关疾病中的重要调控作用及机制，并对lncRNA作为治疗靶标进行了分析和展望。 lncRNA在转录后水平反式调控基因表达 与癌症相关的lncRNA 最后，文章详述了lncRNA在多种病理条件下，包括在神经分化、神经系统疾病、造血、免疫反应、癌症等相关疾病中的重要调控作用及机 .
lncRNA最初被认为是RNA聚合酶II转录的副产物，是一种“噪音”，不具有生物学功能。 然而，今年来的研究表面，lncRNA参与了X染色体沉默、染色体修饰和基因组修饰、转录激活、转录干扰、核内运输等过程，其调控作用正在被越来越多的人研究。lncRNA与编码蛋白质的mRNA相比，大部分lncRNA同样由RNA聚合酶Ⅱ催化转录而来，但其序列保守性不高且表达丰度较低，在组织和细胞中表现出较强的特异性。lncRNA起初被认为是基因组 转录 的“垃圾”，是 RNA聚合酶II 转录的副产物，不具有生物学功能。 . 写在前面长非编码RNA(Long non-coding RNA, lncRNA)是长度大于 200 个核苷酸的非编码 RNA。200个核苷酸的限制可以区分当时已知的功能非编码RNA（如miRNA、miRNA前体）和结构非编码RNA（如tRNA、rRNA）。可想而知，lncRNA是个大杂烩，种类繁多，功能复杂。 随着转录组测序的大规模应用，大量的lncRNA被发现。如果 . Many lncRNA genes are located in the vicinity of TF genes 9,58,59, and in numerous studies the knockout of a lncRNA has led to moderately increased expression of a TF gene in the same TAD (Table 1).
Recent examples of such lncRNA interactions in general 66, and especially of the lncRNA XIST and its associated RNA-binding proteins SPEN 67 and the ubiquitous TDP43 (ref. 68), underline the .
由於此網站的設置，我們無法提供該頁面的具體描述。 Nevertheless, lncRNA isoform-specific studies are gaining traction, shedding light on lncRNA localization and function. For example, the lncRNA FAST (FOXD3-AS1) is positionally conserved in its sequence, but not conserved in . LncRNA的表达有着比mRNA更强的组织和细胞类型特异性，且与发育、病理等过程中基因表达的精确时空调控密切相关。. 在过去几年里国家自然科学基金批准的RNA相关项目中，lncRNA相关的项目占去近半壁江山。. 因此针对lncRNA的进一步研究，可以预见的是可以获得更 .Explore the emerging field of long non-coding RNA (lncRNA) and its significance in RNA biology over the past decades.LincRNA序列的获取有以下两种途径：①可参考LncRNA (Long non-coding RNA)序列的获取，只是在获得LncRNA的序列后需确认该LncRNA为LincRNA；②通过检索LincRNA的研究论文获取其序列，很多LincRNA的序列会在附件中包含或者文章提供链接地址。
長鎖ノンコーディングRNA（lncRNA ） タンパク質をコードしないノンコーディングRNAの一種。一般に、約200塩基以上のものを指す。全長にわたる保存性は高くないが、反復配列やウィルス由来の .lncrna lncrna in cancer 长链非编码RNA(lncRNA)是一类转录本长度超过200nt的RNA分子，它们并不编码蛋白，而是以RNA的形式在多种层面上（表观遗传调控、转录调控以及转录后调控等）调控基因的表达水平。lncRNA起初被认为是基因组转录的“噪音”，是RNA聚合酶II转录的副产物，不具有生物学功能。
知乎专栏 - 随心写作，自由表达 - 知乎知乎专栏 - 随心写作，自由表达 - 知乎 LncRNA对肿瘤进展的贡献以及驱动其表达的调控机制是热点研究领域。 PNUTS基因的pre-RNA在不同条件下能剪切成两种产物：lncRNA-PNUTS和正常mRNA-PNUTS,两种分子在肿瘤中发挥着不同作用，此研究详细的揭示其产生的剪切机制及两种分子 .
They disrupt lncRNA spatial structure or lncRNA–protein interaction and will overcome the extra obstacles to the delivery of ASO/siRNA. These are based on the decipherment of lncRNAs functions in a definite disease, the appropriate structure within the exact lncRNA, and favorable “pockets” that can be stably bound by ligand molecules.Explore the general analysis process of circRNA, including background knowledge and applications to lncRNA studies.
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lncrna|lncrna in cancer